Sunday, 2ndOctober 2011
18.00 - 18.10 | Opening | Welcome and opening remarks | Local hosts |
18.10 - 19.00 | KEY NOTE LECTURE: New Perspectives on Osteogenesis Imperfecta | Joan Marini, USA | |
19.00 - 19.10 | Welcome address of the President of OIFE | Ute Wallentin, Germany | |
19.10 - 19.30 | From the history of health care in Dubrovnik | Vinicije Lupis, Croatia | |
19.30 | Welcome Cocktail |
Monday, 3rdOctober 2011
Session 1 | Classification - Genetics: genotype - phenotype | ||
Session 1a | Classification | ||
Chair: David Sillence (Australia) | |||
Moderator: Anne de Paepe (Belgium) | |||
08.45 - 09.05 | IL1 | INVITED LECTURE: Clinico-molecular findings in a chort of 34 COL1A1/COL1A2 mutation-negative OI patients - the Ghent experience | Anne De Paepe, Belgium |
09.05 - 09.15 | Discussion | ||
09.15 - 09.25 | 1-O-CG1 | Consortium for OI mutations in the helical region of type I collagen: an updated analysis | Antonella Forlino, Italy |
09.25 - 09.35 | 1-O-CG2 | Osteogenesis imperfecta 2011 | David Sillence, Australia |
09.35 - 09.50 | 1-O-CG3 | Genetic heterogeneity in OI warrants a revised Sillence classification | Fleur van Dijk, The Netherlands |
09.50 - 10.00 | 1-O-CG4 | The spectrum of collagen I mutations causing OI in Sweden - a study of 136 families | Katarina Lindahl, Sweden |
10.00 - 10.20 | Discussion | ||
Session 1b | Dominant OI | ||
10.20 - 10.30 | 1-O-CG5 | Clinical presentation of mutations in type I procollagen that interfere with normal processing of the alpha 1(I) collagen N-propeptide domain | Fransiska Malfait, Belgium |
10.30 - 10.40 | 1-O-CG6 | Biochem. and clinical outcome of mutations in the C-propeptide encoding domains of the COL1A1 and COL1A2 gene | Sofie Symoens, Belgium |
10.40 - 10.50 | 1-O-CG7 | High resolution melting/qPCR analysis for simultaneous screening of Col1 point mutations and copy nr variations | F. V. Gentile, Italy |
10.50 - 11.05 | Discussion | ||
11.05 - 11.30 | Coffee Break // Poster Viewing | ||
Session 1c | New Genes that Interact with collagen | ||
Chair: Oliver Semler (Germany) | |||
Moderator: Raymond Dalgleish (United Kingdom) | |||
11.30 - 11.40 | 1-O-CG8 | Exome sequencing identifies truncating mutations in human SERPINF1 in autosomal-recessive OI | Oliver Semler, Germany |
11:40 - 11:50 | 1-O-CG9 | Defects of SERPINF1 cause progressively deforming recessive OI with normal collagen I | Giacomo Venturi, Italy |
11:50 - 12:00 | 1-O-CG10 | Recessive OI probands in a Palestinian pedigree and homoygous for mutation in different genes (FKBP10/PPIB) | Aileen Barnes, USA |
12:00 - 12:10 | 1-O-CG11 | Minning possible OI-causing mutations from the 1000 Genomes Project | Raymond Dalgleish, United Kingdom |
12:10 - 12:20 | 1-O-CG12 | A SOST promoter polymorphism associates with fracture in OI and SOST expression in human bone | Frederic Jehan, France |
12:20 - 12:30 | 1-O-CG13 | Variable OI phenotype that overlaps with Bruck Syndrome and results from mutations in FKBP10 | Ulrike Schwarze, USA |
12.30 - 13:00 | Discussion | ||
13.00 - 14.00 | Lunch | ||
Session 2 | OI in adults | ||
Chair: Lena L. Wekre (Norway) | |||
Moderator: Peter Smith (USA) | |||
14.00 - 14.20 | IL2 | INVITED LECTURE: A review of dominant and recessive OI cases in the experience of the Italian collaborative group | Monica Mottes, Italy |
14.20 - 14.30 | Discussion | ||
14.30 - 14.40 | It doesn't stop at 18 - Special concerns from the perspective of OI adults | Taco van Welzenis OIFE, The Netherlands | |
14.40 - 14.50 | 2-O-AD1 | Spinal cord deformities in adults with OI | Lena L. Wekre, Norway |
14.50 - 15.00 | 2-O-AD2 | Functional outcomes following spinal fusion in children with OI | Stephanie Gould, Canada |
15.00 - 15.10 | 2-O-AD3 | Anesthesia in Patients with OI undergoing Orthopaedic Surgery | Branko Tripković, Croatia |
15.10 - 15.20 | 2-O-AD4 | Analysis of push off power reduction in children with type I OI | Peter Smith, USA |
15.20 - 15.30 | 2-O-AD5 | Quality of life in children and adolescents with OI - qualitative interview based study | Clare Hill, United Kingdom |
15.30 - 15.40 | 2-O-AD6 | The OI Foundation linked clinical research centers longitudinal study | V. Reid Sutton, USA |
15.40 - 15.50 | 2-O-AD7 | Vitamin D status among pediatric patients with OI | Richard Kruse, USA |
15.50 - 16.30 | Discussion | ||
16.30 - 17.00 | Coffee Break // Poster Viewing | ||
Session 3 | Secondary Features of OI | ||
Chair: Freya Swinnen (Belgium) | |||
Moderator: Zoran Radunovic (Norway) | |||
17.00 - 17.10 | S3-O-SF1 | Association between BMD and hearing loss in OI | Freya Swinnen, Belgium |
17.10 - 17.20 | 3-O-SF2 | Missing teeth in patients with OI | Janna Waltimo-Siren, Finland |
17.20 - 17.30 | 3-O-SF3 | Prevalence of valve regurgitations in adults with OI | Zoran Radunovic, Norway |
17.30 - 17.45 | Discussion | ||
Tuesday, 4thOctober 2011
Session 4 | Orthopaedic | ||
Chair: Darko Antičević (Croatia) | |||
Moderator: Francois Fassier (Canada) | |||
08.45 - 09.05 | IL3 | INVITED LECTURE: A team work - a key for success | Francois Fassier, Canada |
09.05 - 09.15 | Discussion | ||
09.15 - 09.25 | 4-O-OP1 | OI: deformities and fractures treatment, our experience with ten nails and | |
Fassier-Duval telescopic rod | Maria di Domenica, Italy | ||
09.25 - 09.35 | 4-O-OP2 | Fassier-Duval telescopic IM system in children with OI | Heim Shtarker, Israel |
09.35 - 09.45 | 4-O-OP3 | Proximal migration of femoral telescopic rod in children with OI | Kang Lee, Republic of Korea |
09.45 - 09.55 | 4-O-OP4 | Surgery can change patient's life | Jose Parra, Spain |
09.55 - 10.05 | 4-O-OP5 | Long term effects of operative treatment of severe scoliosis in OI | Arjan G.J. Harsevoort, The Netherlands |
10.05 - 10.15 | 4-O-OP6 | Operative Treatment of the Upper Extremity in OI | Mathias Rogalski, Germany |
10.15 - 10.25 | 4-O-OP7 | The upper extremity in OI: orthopaedic indications and treatment requirements | Thomas Wirth, Germany |
10.25 - 11.00 | Discussion | ||
11.00 - 11.30 | Coffee Break // Poster Viewing | ||
Session 5 | Bone Biology | ||
Chair: Nick Bishop (United Kingdom) | |||
Moderator: Dragan Primorac (Croatia) | |||
11.30 - 11.50 | IL4 | INVITED LECTURE - Title -TBA | Peter Byers, USA |
11.50 - 12.00 | Discussion | ||
12.00 - 12.10 | 5-O-BB1 | Osteogenesis impairment in bone marrow mesenchymal stem cells from the murine model BrtlIV | Roberta Giola, Italy |
12.10 - 12.20 | 5-O-BB2 | Reduced trabecular bone score in patients with OI type 1 compared with healthy controls | Lars Folkestad, Denmark |
12.20 - 12.30 | 5-O-BB3 | The ratio of urinary pyridinoline to deoxypyridinoine crosslinks - a promising diagnostic tool in OI | Mariane Rohrbach, Switzerland |
12.30 - 12.40 | 5-O-BB4 | Alterations of bone structure measured by High Resolution-pQCT in adult patients with OI | Roland Kocijan, Austria |
12.40 - 13.00 | Discussion | ||
13.00 - 14.30 | Lunch | ||
Session 6 | Mouse Models | ||
Chair: Cathleen Raggio (USA) | |||
Moderator: Peter Byers (USA) | |||
14.30 - 14.40 | 6-O-MM1 | Proteomic analysis of skin from BrtIV OI mice: new insight on phenotypic variability | Antonella Forlino, Italy |
14.40 - 14.50 | 6-O-MM2 | Cellular dysregulation of gene expression may contribute to matrix hypermineralization in OI | Wayne Cabral, USA |
14.50 - 15.00 | 6-O-MM3 | Osteoblast differntiation pattern associated with improved bone | Adi Reich, USA |
phenotype in homozygous OI brtl mice | |||
15.00 - 15.15 | Discussion | ||
15.15 - 15.45 | Coffee Break // Poster Viewing | ||
Session 7 | Bisphosphonates | ||
Chair: Ingeborg Barišić (Croatia) | |||
Moderator: Francis Glorieux (Canada) | |||
15.45 - 16.05 | IL5 | INVITED LECTURE: Oral bisphosphonate therapy in children with OI | Nick Bishop, UK |
16.05 - 16.15 | Discussion | ||
16.15 - 16.25 | 7-O-BP1 | Effects of bisphosphosnates on the prevalence of scoliosis in children with severe OI | Matthijs Baas, The Netherlands |
16.25 - 16.35 | 7-O-BP2 | Comparsion of treatment with neridrronate or pamidronate in children with OI | Oliver Semler, Germany |
16.35 - 16.45 | 7-O-BP3 | The role of multidisciplinary team in management of hypokinetic osteoporosis in OI | Natalia Belova, Russia |
16.45 - 16.55 | 7-O-BP4 | No osteonecrosis of the jaw in children and adolescent treated with nerodronate for OI | Elena Monti, Italy |
16.55 - 17.05 | 7-O-BP5 | Evaluation of serum calcium and phosphorus nadir after pamidronate in infants with severe OI | Hamilton Menezes Filho, Brazil |
17.05 - 17.30 | Discussion |
Wednesday, 5thOctober 2011
Session 8 | New Perspectives | ||
Chair: Antonela Forlino (Italy) | |||
Moderator: Joan Marini (USA) | |||
9.00 - 9.30 | WORKSHOP: Complex Problems in OI | Orthopaedic panel | |
9.30 - 9.40 | 8-O-NP1 | Short-term sclerostin antibody therapy is anabolic and reduces fracture propensity in | Ken Kozloff, USA |
in Brtl/+ OI mouse | |||
9.40 - 9.50 | 8-O-NP2 | Sclerostin antibody increased bone mass and reduced fractures in OI mice | J.Pierre Devogelaer, Belgium |
09.50 - 10.00 | 8-O-NP4 | Gene therapy approach using siRNA/shRNA in BrtlIV fibroblasts for the treatment of classical OI | Antonella Forlino, Italy |
10.00 - 10.20 | IL7 | INVITED LECTURE: The role of P3H1, CRTAP and CypB collagen folding, processing and disease | Hans Peter Bächinger, USA |
10.20 - 10.40 | Discussion | ||
Session 9 | New Developments in Research on OI | ||
Chair: Monica Mottes (Italy) | |||
Moderator: Francis Glorieux (Canada) | |||
10.40 - 11.30 | KEY NOTE LECTURE: Understanding pathophysiology and defining treatment in OI: from the past to the future |
Francis Glorieux, Canada | |
11.30 - 11.40 | Closing remarks | ||
11.40 - 12.30 | Coffee Break |